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76 results

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HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.
Chen L, Guo P, He Y, Chen Z, Chen L, Luo Y, Qi L, Liu Y, Wu Q, Cui Y, Fang F, Zhang X, Song T, Guo H. Chen L, et al. Cell Death Dis. 2018 May 1;9(5):513. doi: 10.1038/s41419-018-0534-9. Cell Death Dis. 2018. PMID: 29725020 Free PMC article.
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers are hepatocellular carcinoma (HCC). Currently, HCC patient prognosis is unsatisfactory due to high metastasis and/or post-surgical recurrenc …
Liver cancer is the second most common cause of cancer-related death worldwide. Approximately 70-90% of primary liver cancers …
Methylation of SOX1 and VIM promoters in serum as potential biomarkers for hepatocellular carcinoma.
Liu XY, Fan YC, Gao S, Zhao J, Chen LY, Li F, Wang K. Liu XY, et al. Neoplasma. 2017;64(5):745-753. doi: 10.4149/neo_2017_513. Neoplasma. 2017. PMID: 28592127
This study aimed to investigate the diagnostic value of SRY (sex determining region Y)-box 1 (SOX1) and Vimentin (VIM) promoter methylation for HCC. The study included 360 subjects, 240 patients with HCC, 29 with liver cirrhosis (LC), 66 with chronic hepatitis B (CH …
This study aimed to investigate the diagnostic value of SRY (sex determining region Y)-box 1 (SOX1) and Vimentin (VIM) promoter methy …
MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities.
Sequera C, Grattarola M, Holczbauer A, Dono R, Pizzimenti S, Barrera G, Wangensteen KJ, Maina F. Sequera C, et al. Cell Death Dis. 2022 Nov 24;13(11):994. doi: 10.1038/s41419-022-05411-6. Cell Death Dis. 2022. PMID: 36433941 Free PMC article.
Results showed that increased MYC and MET expression in hepatocytes is sufficient to induce liver tumorigenesis even in the absence of pre-existing injuries associated with a chronic disease state. ...Together, these findings highlight a subgroup of HCC characterised by MY …
Results showed that increased MYC and MET expression in hepatocytes is sufficient to induce liver tumorigenesis even in the absence o …
COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial-mesenchymal transition in liver cancer cells.
Zhang H, Wang Y, Ding H. Zhang H, et al. Clin Transl Oncol. 2021 Oct;23(10):2078-2089. doi: 10.1007/s12094-021-02611-y. Epub 2021 Apr 23. Clin Transl Oncol. 2021. PMID: 33891266
OBJECTIVE: Collagen type IV alpha 1 (COL4A1) exerts tumor-promoting functions in several tumors. However, its role in liver cancer remains not fully understood. Hence, this study aims to investigate the role of COL4A1 in regulating liver cancer cell behaviors and to …
OBJECTIVE: Collagen type IV alpha 1 (COL4A1) exerts tumor-promoting functions in several tumors. However, its role in liver cancer re …
FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway.
Gu C, Wang X, Long T, Wang X, Zhong Y, Ma Y, Hu Z, Li Z. Gu C, et al. Cell Death Dis. 2018 May 29;9(6):654. doi: 10.1038/s41419-018-0695-6. Cell Death Dis. 2018. PMID: 29844309 Free PMC article.
Enhanced expression of FSTL1 distinctly increased cell migration and invasion in vitro, as well as promoting liver metastasis of CRC in vivo. Conversely, knockdown of FSTL1 expression significantly repressed invasion and metastasis of CRC. ...Furthermore, this effect of FS …
Enhanced expression of FSTL1 distinctly increased cell migration and invasion in vitro, as well as promoting liver metastasis of CRC …
HOXB9 Overexpression Promotes Colorectal Cancer Progression and Is Associated with Worse Survival in Liver Resection Patients for Colorectal Liver Metastases.
Martinou E, Moller-Levet C, Karamanis D, Bagwan I, Angelidi AM. Martinou E, et al. Int J Mol Sci. 2022 Feb 18;23(4):2281. doi: 10.3390/ijms23042281. Int J Mol Sci. 2022. PMID: 35216396 Free PMC article.
We aimed to explore the role of HOXB9 in CRC progression and its association with OS in colorectal liver metastases (CRLM). We analysed differential HOXB9 expression in CRC using the Tissue Cancer Genome Atlas database (TCGA). ...In vitro, HOXB9 overexpression increased ce …
We aimed to explore the role of HOXB9 in CRC progression and its association with OS in colorectal liver metastases (CRLM). We analys …
lncRNA TPT1-AS1 knockdown inhibits liver cancer cell proliferation, migration and invasion.
Li H, Jin J, Xian J, Wang W. Li H, et al. Mol Med Rep. 2021 Nov;24(5):782. doi: 10.3892/mmr.2021.12422. Epub 2021 Sep 9. Mol Med Rep. 2021. PMID: 34498708 Free PMC article.
Long non-coding RNA (lncRNA) tumor protein translationally controlled 1 antisense RNA 1 (TPT1-AS1) serves as an oncogene in several tumors, including ovarian and cervical cancer. However, the functional role of TPT1-AS1 in liver cancer (LC) is not completely understood. Th …
Long non-coding RNA (lncRNA) tumor protein translationally controlled 1 antisense RNA 1 (TPT1-AS1) serves as an oncogene in several tumors, …
Hepatocellular carcinoma (HCC) tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) tumor microenvironment.
Santagata S, Rea G, Castaldo D, Napolitano M, Capiluongo A, D'Alterio C, Trotta AM, Ieranò C, Portella L, Di Maro S, Tatangelo F, Albino V, Guarino R, Cutolo C, Izzo F, Scala S. Santagata S, et al. Hepatol Int. 2024 Apr;18(2):568-581. doi: 10.1007/s12072-023-10537-6. Epub 2023 May 4. Hepatol Int. 2024. PMID: 37142825 Free PMC article.
BACKGROUND AND PURPOSE: While HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. To evaluate the immune aspects of these two different environments, peripheral blood-(PB), peritumoral-(PT) and tumoral tissues-(TT) from HCC …
BACKGROUND AND PURPOSE: While HCC is an inflammation-associated cancer, CRLM develops on permissive healthy liver microenvironment. T …
MicroRNA-520c-3p Modulates Doxorubicin-Chemosensitivity in HepG2 Cells.
Ragheb MA, Soliman MH, Elzayat EM, Mohamed MS, El-Ekiaby N, Abdelaziz AI, Abdel-Wahab AA. Ragheb MA, et al. Anticancer Agents Med Chem. 2021;21(2):237-245. doi: 10.2174/1871520620666200502004817. Anticancer Agents Med Chem. 2021. PMID: 32357822
OBJECTIVE: Investigating the role of microRNA-520c-3p (miR-520c-3p) in the enhancement of the anti-tumor effect of DOX against HepG2 cells. METHODS: Expression profile for liver-related miRNAs (384 miRNAs) has been analyzed on HepG2 cells treated with DOX using qRT-PCR. mi …
OBJECTIVE: Investigating the role of microRNA-520c-3p (miR-520c-3p) in the enhancement of the anti-tumor effect of DOX against HepG2 cells. …
Primary solitary fibrous tumors of liver: a case report and literature review.
Liu Q, Liu J, Chen W, Mao S, Guo Y. Liu Q, et al. Diagn Pathol. 2013 Dec 2;8:195. doi: 10.1186/1746-1596-8-195. Diagn Pathol. 2013. PMID: 24294990 Free PMC article. Review.
Immunohistochemically, these spindle tumor cells showed diffuse Vim and Bcl-2 positive reactivity, but S-100 protein and HMB45 were negative. The post-operative course was uneventful. Solitary fibrous tumors of the liver, although rare, should be differentiated from …
Immunohistochemically, these spindle tumor cells showed diffuse Vim and Bcl-2 positive reactivity, but S-100 protein and HMB45 were n …
76 results